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Hormone Correction Improves and Reverses Many Aspects of Aging, Especially in Seniors
During the last five years, primarily in Belgium and the USA, physicians specializing in anti-aging have become active in slowing or reversing aging in those patients desiring more than Medicare (or, as I prefer to call it, “Mediocre-care”) currently provides. Their methods have nothing to do with cosmetics or dermatological treatments. Indeed, several physicians of my acquaintance have even specialized in patients over the age of 80, since current treatment often abandons them or prescribes drugs not tested on the elderly. These forward-thinking physicians start slowly by correcting for nutritional, or nutraceutical, deficiencies, such as the supplementation of a daily tablet of sublingual vitamin B12 and ubiquinol (a reduced formed of CoQ10 taken 100mg daily). Only sublingual B12 helps to regain or enhance muscle and neurological control. Ubiquinol is a key nutraceutical for preventing heart problems, and patients are often lacking it when taking synthetic drugs, especially the ever-popular statin medications.
These forward-thinking physicians monitor their senior patients extensively with frequent referrals to other medical specialists. They start them on a mild exercise program, such as kicking one’s legs in a swimming pool for at least an hour daily. Eventually, after evaluating and monitoring test results, they began to treat them with very low doses of hormones, such as natural desiccated thyroid (See ERFA Thyroid Natural® or Armour® starting with a quarter grain daily) and liposomal testosterone cream (often a 50mg daily starting dose for men or a 3mg daily starting dose for women; a starting dose of 150-mg or more is totally unwarranted, especially in seniors). In both men and women, this last hormone is merited due to the fact that 100-year-old Okinawan women (the oldest living people on the planet) have, on average, more than double the amount of testosterone than 70-year-old American women. Secondly, the faculty of the Harvard Medical School has given its stamp of approval to its professor, Abraham Morgentaler, and his new book, Testosterone for Life,³ as the new health standard, even for men with existing prostate cancer! (Another vital hormone often slated for correction in seniors is DHEA (dehydroepiandrosterone).
Physicians specializing in anti-aging have learned to slowly step-up monthly hormone dosages in older patients, while carefully monitoring them to improve their health and help them regain mental and physical functions. Side effects may occur only when patients overdose, or if dosage is increased too rapidly.
Daily Dosing with the IGF-1/ HGH Cocktail
Eventually, after several months, patients advance to the final step with HGH and IGF-1 therapy. This step is the most powerful tool that anti-aging medicine has to offer, namely a twice-daily cocktail of human growth hormone (HGH) combined with the polypeptide, IGF-1. However, please keep in mind that this cocktail will only work if supported by;
(A) Sufficient anabolic hormones, such as testosterone, DHEA, estradiol, etc., and
(B) Sufficient thyroid (T3 and T4) and cortisone
(C) Sufficient protein and amino acids. All of these components plus
(D) Regular exercise contributes to prevent the body from deteriorating, and they build the body up physically and mentally.
A junk food diet will not work. Please keep in mind that during aging, shrinking, wrinkling, and wasting are caused by lack of A, B, C and D.
This final treatment employs IGF-1, which must be stepped up gradually, starting with 0.01mg every other day, and ending with a maintenance dose of 0.10mg daily after approximately two and a half months.  I describe the exact step-up procedure as follows.
Every ten days, increase dosage starting with:
0.01mg once a day and injected only every other day for the first ten days.
 
For the second ten-day period, inject 0.005mg twice daily during mornings and before bedtime.
For the third ten-day period, inject 0.01mg twice daily.
For the fourth ten-day period, inject 0.02mg twice daily.
For the fifth ten-day period, inject 0.03mg twice daily.
For the sixth ten-day period, inject 0.04mg twice daily.
For the seventh ten-day period, inject 0.05mg twice daily. This is the maintenance dose totaling 0.1mg daily.  Further increases may be warranted according to benefits, signs, and symptoms as listed at the end of this paper. Patients should watch for overdose signs and report them to a knowledgeable physician specializing in anti-aging or age management medicine.
Physical Appearance: The cocktail may improve and greatly reduce wrinkles and the saggingand atrophying of the body.
Organ Function: The cocktail allows people to maintain excellent health by improving and repairing muscles and inner organs, including the brain, heart, kidneys, joints, lungs, and nerves.
Repair Systems: The cocktail reduces cellular damages and accelerates cellular repair.
Free Radical Formation: The cocktail stimulates antioxidant activity, especially l-glutathione, and limits excessive free radical formation.
Emotional Improvement: The cocktail promotes increased inner peace, psychic well-being, self-assurance, leadership, self-confidence (especially combined with oxytocin), problem solving, and reduced stress.
Improvement in elevated glucose and insulin: The cocktail benefits those with both Type I and II diabetes and lowers risk for both hypoglycemia and increased body fat. It also increases lean muscle mass.
Improvement in immune defenses.
Inhibits undesirable apoptosis and limits healthy cell proliferation.
Telomere Length: A reduced serum IGF-1 correlates with reduced telomere length.
Degradation of physical appearance, premature aging, and severely impaired quality of life.
Obesity, droopy muscles, droopy eyelids, thinner lips, thinner jaw bones, thinner eyebrows, thinner nose (tip pointed downward), thinner skin, and droopy abdomen with stretch marks.
Bowed back (thoracic kyphosis) and excessively curved lumbar back (hyperlordosis).
Atrophy of the jaws, nose, chin, ears, hands (atrophic metacarpal bones), feet, bones, genitals, nails (as evidenced by longitudinal lines), sagging cheeks, and loose skin folds under the chin.
Sore feet after long walks, fallen arches, atrophied soles of the feet, flat feet, and sagging inner thighs.
Energy compromised as evidenced by exhaustion with little or no recovery.
Energy compromised by feelings of deep physical degradation.
Poor stress tolerance.
Great difficulty multitasking due to lack of concentration or feeling powerless.
Low self-esteem and lack of self-confidence.
Chronic anxiety, lack of inner peace, and a tendency to become easily depressed.
Irregular sleeping habits.
The average dose for adults with mild deficiency is 0.2 mg daily; however lower IGF-1 doses prescribed here are sufficient when combined with 0.08mg HGH daily. I label this my ‘IGF-1/HGH cocktail.’ In other words, growth hormone should be added to this twice-daily mixture at a dosage of approximately one-fourth of a unit HGH (0.04mg twice daily). Typically, I mix both HGH and IGF-1 in a BD 31 gauge insulin syringe that is sufficient for three or four injections. In between injections, I store the syringe in the refrigerator along with my ampoules of HGH and IGF-1.
(Note that liquid solutions of IGF-1 but not HGH will deteriorate if left unrefrigerated. Also, it is advisable to dissolve IGF-1 in isotonic water containing 0.6% acetic acid. The acetic acid balances the pH at about 4.5 and protonates the polypeptide IGF-1 molecule for optimal effect.)
General Benefits of the HGH/IGF-1 Cocktail
I usually notice benefits from the cocktail after approximately the second or third month. First, I observe that brain processing speed increases significantly; 65-year-olds begin to show information processing speeds typical of younger people. For example, I and others over age 50 have reacted faster in emergency traffic situations that require quick thinking and physical dexterity behind the wheel. In other words, one reacts faster to ambulances and fire trucks than other drivers.
Secondly, I have become a strong sprinter, powered by balanced nutrients and hormones, especially the HGH plus IGF-1 cocktail. One day, I tied my powerful Airedale terrier, Maggie, to a wooden chair at the Whole Foods™ market. Soon afterwards, Maggie became frightened and took off running with the chair dragging behind her. Then, two young Whole Foods™ employees ran after the market’s vanishing chair. The dog and chair disappeared to a distant parking lot. In a panic, I ran full-speed after the dog and chair, and I quickly passed the two huffing and puffing twenty-somethings and caught up with the escaping Maggie. The winded and exhausted Whole Foods™ youngsters commented that I must be a marathon runner, which I definitely am not (I am a somewhat lethargic scientist)! This remarkable cocktail returned to me my physical and mental agility, presumably lost many decades ago.
Specific Benefits of the HGH/IGF-1 Cocktail
However, please note carefully that I could not just start off on the cocktail without other supporting hormones and nutrients. All of these components work in synergy with one another and allow the body and mind to multitask with the environment. As Dr. Thierry Hertoghe often says, hormones and nutrients must be well-balanced if one wants to escape many of the ravages of aging. In his Hormone Handbook, Vol.2,² he states specifically the following as improvements with the HGH/IGF-1 cocktail, if other hormones and nutraceuticals are first balanced:
Signs and Symptoms of Aging Identified
According to Dr. Hertoghe and me, many of the following signs and symptoms of aging are often helped with the cocktail, assuming all other hormones and nutritional deficiencies are first addressed, which are as follows:
Conclusions
The HGH/IGF-1 cocktail may sound like a new fountain of youth, but this view is unfortunately incorrect. The cocktail is merely one major step forward in avoiding many of the ravages of aging and in enhancing health, especially in people over the age of 50. The cocktail is the here-and-now, cutting-edge solution to slowing and reversing aging while we await developments in gene therapy that promise to correct and renew our aging bodies at the genetic level (in other words, the altering and reprogramming of our epigenome).