RBC turnover takes anywhere from 45-90 days, so typically that is how long it would take to see a difference if all other variables remained the same. If you did other things to lower your RBC then it could speed up the process. I have been taking methylene blue at 15 mg morning and afternoon and saw a 5% reduction in 30 days. I had removed all other items I used to keep my RBC, HCT and hemoglobin in check, because I wanted to see how it would work on its own and it performed very well. I have added everything else back in and will do labs mid Feb.