Road2HardCoreIron

Also one of the only products Wound care doctors will use to wrap woulds that do not heal.  Must healing is withing 2-3 weeks.   Seen results as quick as 10 day.  Great for debritic ulcers


. doi: 10.1111/wrr.12537. Epub 2017 May 9.
The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial
Mansooreh Momen-Heravi 1 2, Elham Barahimi 1, Reza Razzaghi 1, Fereshteh Bahmani 3, Hamid Reza Gilasi 4, Zatollah Asemi 3
Affiliations expand
PMID: 28395131 DOI: 10.1111/wrr.12537
Abstract
This study was performed to determine the effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer. The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 40-85 years old) with grade 3 diabetic foot ulcer. Participants were randomly divided into two groups (30 participants in each group) to take either 220 mg zinc sulfate supplements containing 50 mg elemental zinc or placebo daily for 12 weeks. After the 12-week intervention, compared with the placebo, zinc supplementation was associated with significant reductions in ulcer length (-1.5 ± 0.7 vs. -0.9 ± 1.2 cm, p = 0.02) and width (-1.4 ± 0.8 vs. -0.8 ± 1.0 cm, p = 0.02). In addition, changes in fasting plasma glucose (-40.5 ± 71.0 vs. -3.9 ± 48.5 mg/dl, p = 0.02), serum insulin concentration (-8.0 ± 15.4 vs. +1.1 ± 10.3 µIU/ml, p = 0.009), homeostasis model of assessment-estimated insulin resistance (-3.9 ± 7.1 vs. +0.8 ± 5.9, p = 0.007), the quantitative insulin sensitivity check index (+0.01 ± 0.03 vs. -0.002 ± 0.02, p = 0.04) and HbA1c (-0.5 ± 0.8 vs. -0.1 ± 0.5%, p = 0.01) in the supplemented group were significantly different from the changes in these indicators in the placebo group. Additionally, significant increases in serum HDL-cholesterol (+4.1 ± 4.3 vs. +1.1 ± 5.1 mg/dl, p = 0.01), plasma total antioxidant capacity (+91.7 ± 213.9 vs. -111.9 ± 188.7 mmol/L, p < 0.01) and total glutathione (+68.1 ± 140.8 vs. -35.0 ± 136.1 µmol/L, p = 0.006), and significant decreases in high sensitivity C-reactive protein (-20.4 ± 24.6 vs. -6.8 ± 21.3 µg/ml, p = 0.02) and plasma malondialdehyde concentrations (-0.6 ± 0.9 vs. -0.2 ± 0.7 µmol/L, p = 0.03) were seen following supplementation with zinc compared with the placebo. Zinc supplementation for 12 weeks among diabetic foot ulcer patients had beneficial effects on parameters of ulcer size and metabolic profiles.

© 2017 by the Wound Healing Society.

PubMed Disclaimer

Similar articles
The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Razzaghi R, Pourbagheri H, Momen-Heravi M, Bahmani F, Shadi J, Soleimani Z, Asemi Z.
J Diabetes Complications. 2017 Apr;31(4):766-772. doi: 10.1016/j.jdiacomp.2016.06.017. Epub 2016 Jun 23.
PMID: 27363929 Clinical Trial.
The beneficial effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Mohseni S, Bayani M, Bahmani F, Tajabadi-Ebrahimi M, Bayani MA, Jafari P, Asemi Z.
Diabetes Metab Res Rev. 2018 Mar;34(3). doi: 10.1002/dmrr.2970. Epub 2017 Dec 21.
PMID: 29193662 Clinical Trial.
Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
Razzaghi R, Pidar F, Momen-Heravi M, Bahmani F, Akbari H, Asemi Z.
Biol Trace Elem Res. 2018 Feb;181(2):207-215. doi: 10.1007/s12011-017-1056-5. Epub 2017 May 24.
PMID: 28540570 Clinical Trial.
Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Soleimani Z, Hashemdokht F, Bahmani F, Taghizadeh M, Memarzadeh MR, Asemi Z.
J Diabetes Complications. 2017 Sep;31(9):1394-1400. doi: 10.1016/j.jdiacomp.2017.06.010. Epub 2017 Jun 28.
PMID: 28716357 Clinical Trial.
The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
Afzali H, Jafari Kashi AH, Momen-Heravi M, Razzaghi R, Amirani E, Bahmani F, Gilasi HR, Asemi Z.
Wound Repair Regen. 2019 May;27(3):277-284. doi: 10.1111/wrr.12701. Epub 2019 Feb 11.
PMID: 30693609 Clinical Trial.
See all similar articles
Cited by
Association of Blood Trace Elements Levels with Cardiovascular Disease in US Adults: a Cross-Sectional Study from the National Health and Nutrition Examination Survey 2011-2016.
Guo Q, Cai J, Qu Q, Cheang I, Shi J, Pang H, Li X.
Biol Trace Elem Res. 2023 Oct 28. doi: 10.1007/s12011-023-03913-8. Online ahead of print.
PMID: 37891364
Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
Nazari M, Nikbaf-Shandiz M, Pashayee-Khamene F, Bagheri R, Goudarzi K, Hosseinnia NV, Dolatshahi S, Omran HS, Amirani N, Ashtary-Larky D, Asbaghi O, Ghanavati M.
Biol Trace Elem Res. 2023 Oct 23. doi: 10.1007/s12011-023-03895-7. Online ahead of print.
PMID: 37870684 Review.
The association between micronutrient levels and diabetic foot ulcer: A systematic review with meta-analysis.
Kurian SJ, Baral T, Unnikrishnan MK, Benson R, Munisamy M, Saravu K, Rodrigues GS, Rao M, Kumar A, Miraj SS.
Front Endocrinol (Lausanne). 2023 Mar 29;14:1152854. doi: 10.3389/fendo.2023.1152854. eCollection 2023.
PMID: 37065742 Free PMC article.
Therapeutic Utilization of Zinc Supplementation Concurrent with Ozone Therapy Ameliorates Diabetic Foot Ulcer and Attenuates Serum Level of C-reactive Protein- A Case Report Study.
Dadfar R, Khorsandi L, Goujani R, Mousavi SF, Aslani Z.
Adv Biomed Res. 2023 Jan 27;12:18. doi: 10.4103/abr.abr_11_22. eCollection 2023.
PMID: 36926441 Free PMC article.
Trace element zinc and skin disorders.
Zou P, Du Y, Yang C, Cao Y.
Front Med (Lausanne). 2023 Jan 17;9:1093868. doi: 10.3389/fmed.2022.1093868. eCollection 2022.
PMID: 36733937 Free PMC article. Review.
See all "Cited by" articles
Publication types
Randomized Controlled Trial
MeSH terms
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use*
Blood Glucose / metabolism
C-Reactive Protein / metabolism
Diabetic Foot / blood
Diabetic Foot / complications
Diabetic Foot / drug therapy*
Diabetic Foot / metabolism*
Dietary Supplements
Double-Blind Method
Female
Glycated Hemoglobin / metabolism
Humans
Insulin Resistance
Iran
Male
Malondialdehyde / blood
Middle Aged
Severity of Illness Index
Treatment Outcome
Wound Healing / drug effects*
Wound Healing / physiology
Zinc / pharmacology
Zinc / therapeutic use*
Substances
Anti-Inflammatory Agents
Blood Glucose
Glycated Hemoglobin A
hemoglobin A1c protein, human
Malondialdehyde
C-Reactive Protein
Zinc
Associated data
IRCT/IRCT201506215623N46
Related information
MedGen