+- +-

+-User

Welcome, Guest.
Please login or register.
 
 
 
Forgot your password?

+-Stats ezBlock

Members
Total Members: 90
Latest: Wallyd
New This Month: 2
New This Week: 1
New Today: 0
Stats
Total Posts: 4718
Total Topics: 2782
Most Online Today: 29
Most Online Ever: 166080
(September 24, 2023, 08:28:44 pm)
Users Online
Members: 0
Guests: 29
Total: 29

Author Topic: Effects of IGF1 Isoforms on Muscle Growth  (Read 88 times)

0 Members and 1 Guest are viewing this topic.

Big Chicken

  • Welcome to the Muscle Science Board
  • Trade Count: (0)
  • Administrator
  • Hero Member
  • *****
  • Posts: 3298
  • Karma: +8/-1
  • You Think I Can't See U
    • View Profile
    • Road2hardCoreIron.net

  • Total Badges: 32
    Badges: (View All)
    2500 Posts Level 6 Fifth year Anniversary
Effects of IGF1 Isoforms on Muscle Growth
« on: November 13, 2022, 04:37:20 pm »
Aging Cell
. 2019 Jun;18(3):e12954. doi: 10.1111/acel.12954. Epub 2019 Apr 5.
Effects of IGF-1 isoforms on muscle growth and sarcopenia
Francesca Ascenzi 1, Laura Barberi 1, Gabriella Dobrowolny 1, Aline Villa Nova Bacurau 2, Carmine Nicoletti 1, Emanuele Rizzuto 3, Nadia Rosenthal 4 5, Bianca Maria Scicchitano 6, Antonio Musaṛ 1
Affiliations expand
PMID: 30953403 PMCID: PMC6516183 DOI: 10.1111/acel.12954
Free PMC article
Abstract
The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels of inflammatory mediators. Thus, factors that increase muscle mass and promote anabolic pathways might be of therapeutic benefit to counteract sarcopenia. Among these, the insulin-like growth factor-1 (IGF-1) has been implicated in many anabolic pathways in skeletal muscle. IGF-1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF-1Ea and IGF-1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging. We report that only IGF-1Ea expression promotes a pronounced hypertrophic phenotype in young mice, which is maintained in aged mice. Nevertheless, examination of aged transgenic mice revealed that the local expression of either IGF-1Ea or IGF-1Eb transgenes was protective against age-related loss of muscle mass and force. At molecular level, both isoforms activate the autophagy/lysosome system, normally altered during aging, and increase PGC1-α expression, modulating mitochondrial function, ROS detoxification, and the basal inflammatory state occurring at old age. Moreover, morphological integrity of neuromuscular junctions was maintained and preserved in both MLC/IGF-1Ea and MLC/IGF-1Eb mice during aging. These data suggest that IGF-1 is a promising therapeutic agent in staving off advancing muscle weakness.

Keywords: IGF-1; NMJ; aging; autophagy; sarcopenia; skeletal muscle.
This board does not condone the use of any medication.  Members should follow City, State, Federal and your countries laws to obtain proper scripts and use of any medication in discussion. We are a private discussion board only.

Share on Facebook Share on Twitter


 

+-Recent Topics

Why Pakistan Bodybuilders are Dying? by Big Chicken
March 28, 2024, 10:38:07 am

Medical Use of Andriol Capsules by Big Chicken
March 28, 2024, 10:29:07 am

Steroids or Not Steroids Q & A by Big Chicken
March 28, 2024, 07:39:43 am

Naturals Do Not Need More Protein by Big Chicken
March 28, 2024, 07:33:59 am

Pro Bodybuilder Speaks on BBers Bad Habits by Big Chicken
March 28, 2024, 02:35:52 am

Bostin Loyd's mom. Speaks Out by Big Chicken
March 27, 2024, 01:21:50 pm

ZPHC 30 ML Trenbolone A by Big Chicken
March 27, 2024, 09:13:25 am

ZPHC NEW LINE: 30 ml Vials and 50 Mg Anavar 2024 by Big Chicken
March 27, 2024, 08:25:35 am

Fastest Teenager by Big Chicken
March 27, 2024, 05:37:59 am

Role of Estrogen Blockers by Big Chicken
March 26, 2024, 11:37:03 am