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eCollection 2021 Sep.
Synthol systemic complications: Hypercalcemia and pulmonary granulomatosis. A case report
Mersad Alimoradi 1, Ahmad Chahal 2, Elie El-Rassi 3, Karim Daher 3, Gazy Sakr 4
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PMID: 34522373 PMCID: PMC8426527 DOI: 10.1016/j.amsu.2021.102771
Free PMC article
Abstract
Introduction: Synthol injection for body contouring has been used by bodybuilders for some time. We report two extremely rare systemic complications; pulmonary granulomatosis and hypercalcemia, in a woman who has received Synthol injections for buttocks augmentation.

Presentation of case: The case discussed in this report is of a 36-year-old lady who presented for severe hypercalcemia and nephrocalcinosis. Subsequent workup revealed granulomas in the buttocks and in the lungs. Upon questioning, it was discovered that she had received Synthol injection for buttocks augmentation a few months earlier. Labs were consistent with calcitriol mediated hypercalcemia, a phenomenon observed in granulomatous diseases. A diagnosis of foreign body granulomatosis with pulmonary migration and secondary hypercalcemia was made. The patient was started on prednisone and showed an initial positive response.

Discussion: Reported complications of Synthol include pain, muscle deformity, and ulceration at the injection site. Hypercalcemia secondary to foreign body granulomatosis after Synthol injection has been reported only once previously, and here we report a second case. The hypercalcemia is thought to be calcitriol mediated, where overexpression of CYP27B1 in the macrophages forming the granulomas leads to pathological extrarenal calcitriol production. Pulmonary granulomatosis, theorized to be secondary to hematologic migration of the injected material, has never been reported previously with Synthol use.

Conclusion: Synthol injection for body contouring may be a cause of extensive local and pulmonary foreign body granulomatosis leading to calcitriol mediated hypercalcemia. History of cosmetic injections should not be disregarded during history taking.

Keywords: Body contouring; CT, computed tomography; ESWL, extracorporeal shock wave lithotripsy; Fillers complication; Foreign body granulomatosis; Hypercalcemia; KUB, Kidney ureter bladder; Lung granuloma; Nephrocalcinosis; Nephrolithiasis; PET, positron emission tomography; PMMA, polymethylmethacrylate; PTH, parathyroid hormone; Synthol.

© 2021 The Author(s).

Conflict of interest statement
The authors report no conflict of interest with any parties in regards to this research article.