I was reading up on how boron could possibly reduce SHBG, thus increasing free testosterone. I started taking 6 mg a day and noticed a difference in water retention, mood and well being in a matter of days. Now I don't know if it actually had an impact on SHBG, because I didn't have labs done and I know boron can also lower cortisol, but thought it was interesting. My wife started taking it about a month ago and she noticed a difference immediately as well.