I take them pre-fasted cardio, which technically makes it not fasted cardio, and intra-workout to prevent catabolism. If I eat 1.5 hours prior to training and 1-1.5 hours after training that may be a 4-5 hour window without food. In that time, I was breaking muscles down. If you are training hard, the aminos and carbohydrates from your pre-workout meal may last 30 minutes into the workout. After that, there is nothing to prevent your muscles from being used as fuel via gluconeogenesis. Having an intra-workout with carbs and aminos will prevent this.
Aminos taken intra-workout should help with DOMS as they start the recovery process sooner than if you were to just wait and eat.